Fatal hepatic reactions have occurred primarily in patients with serious underlying medical conditions (primarily AIDS or malignancy) and often taking multiple concomitant medications. Sounds strange, but the interaction results in a larger volume of stool and better bowel function. If you notice any other effects, check with your healthcare professional. If home remedies do not help, over-the-counter and prescription medications are available. "Product Information. Six to eight glasses a day is a good rule. Water and fruit juices are best for preventing constipation. As well as improving bowel movements, glucomannan may act as a prebiotic to improve the balance of good bacteria in the gut. 48. Shake the oral suspension (liquid) before you measure a dose. [Ref], Very common (10% or more): Headache (up to 13%), Uncommon (0.1% to 1%): Seizures, dizziness, paresthesia, somnolence, vertigo, visual field defect, taste perversion, hyperkinesia, hypertonia, Frequency not reported: Dysesthesias[Ref], Dry mouth, dyspepsia, and vomiting have also been reported during postmarketing experience. 28. Other options for constipation relief include over-the-counter remedies, such as polyethylene glycol (Miralax, GlycoLax, and many others). Plus, get a FREE copy of the Best Diets for Cognitive Fitness. Culture of peritoneal fluid showed infection with Candida albicans. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Eat shirataki noodles or take a glucomannan supplement. Bottom line: Try eating more high fiber foods. Ann Intern Med 125 (1996): 153, 28. Pickled cucumbers. Many drugs can interact and cause dangerous effects. Short-course vaginal therapy. This is a sugar alcohol that has a laxative effect (56, 57). Depending on your age and sex, adults should get 22 to 34 grams of fiber a day. (2016). Acute generalized exanthematous pustulosis, drug eruption, increased sweating, exfoliative skin disorders (including Stevens-Johnson syndrome, toxic epidermal necrolysis), and alopecia have also been reported during postmarketing experience. Learn more here. Sales of processed foods such as chips, sugary cereals, and macaroni-and-cheese surged in the spring of 2020, as coronavirus-triggered lockdowns took hold in the United States. Learn more about yoga poses for, Constipation occurs when people cannot pass stool as freely as they would like to, and it may cause symptoms including bloating and discomfort. Vaginal infections are often treated with only one pill. Beecker J, Colantonio S "Fixed drug eruption due to fluconazole." Your reactions could be impaired. Am J Kidney Dis 49 (2007): 318-22. Seizures, dizziness, paresthesia, somnolence, tremor, and vertigo have also been reported during postmarketing experience. More frequent side effects include: vomiting. Magnesium helps draw water into your bowel, softening your stool and making it easier to pass. This medicine may rarely cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Neuhaus G, Pavic N, Pletscher M "Anaphylactic reaction after oral fluconazole." Bottom line: Dairy or lactose intolerance may cause constipation in some people. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Learn more about the causes and how to treat or prevent constipation here. Read and follow these instructions carefully. Heart diseaseUse with caution. What is the dose of fluconazole for tinea? A doctor may recommend one of the following types: However, people should not take most of these laxatives on a regular basis without speaking to a doctor. You may take Diflucan with or without food. Uncommon (0.1% to 1%): Insomnia, nervousness, Uncommon (0.1% to 1%): Polyuria, renal pain, changes in renal function tests, Frequency not reported: Membranous nephropathy, Postmarketing reports: Acute renal failure[Ref]. Senna is a popular safe and effective herbal laxative that helps treat constipation (34, 35). Generic name: fluconazole [floo-KOE-na-zole] This medicine is available only with your doctor's prescription. "Fluconazole-related hepatotoxicity in patients with acquired immunodeficiency syndrome." Take natural laxatives. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting. The keys to preventing constipation are simple enough. A person can speak to a doctor or pharmacist about choosing an appropriate laxative. Chronic constipation [Abstract]. eat more high- fiber foods. You may store the oral suspension between 86 F (30 C) and 41 F (5 C), but do not allow it to freeze. If constipation persists, a person can talk to their doctor to identify the cause and find an effective treatment. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Heart rhythm problems (eg, QT prolongation) or. "A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation." (2015). Liu, L. W. C. (2011). It may also contain small amounts of soluble fiber. [Ref], Hypercholesterolemia, hypertriglyceridemia, and hypokalemia have also been reported during postmarketing experience. And if you gave up your healthy diet in favor of starchy sweets, you may have experienced bouts of constipation. Portions of this document last updated: Feb. 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/fluconazole-oral-route/side-effects/DRG-20071428. All rights reserved. [Ref], Very common (10% or more): Nausea, abdominal pain, diarrhea, vomiting, Uncommon (0.1% to 1%): Constipation, flatulence, loose stools, dry mouth, Frequency not reported: General abdominal discomfort[Ref], Very common (10% or more): Increased ALT, increased AST, Uncommon (0.1% to 1%): Serum transaminase elevations, cholestasis, jaundice, increased bilirubin, Rare (less than 0.1%): Serious hepatic reactions, hepatic toxicity (including fatalities), hepatic failure, hepatocellular necrosis, hepatitis, hepatocellular damage, Frequency not reported: Hepatic reactions (ranging from mild transient transaminase elevations to clinical hepatitis, fulminant hepatic failure [including fatalities]), transient hepatic reactions (including hepatitis, jaundice), elevated liver function tests (transient and asymptomatic), cholestatic jaundice, fatal hepatic necrosis, increased plasma levels of hepatic enzymes[Ref]. Rare cases of exfoliative dermatitis and ulcerative eruptions consistent with Stevens-Johnson syndrome have been reported in association with hypersensitivity reactions. Can diet help improve depression symptoms? Dahl, W. J., & Stewart, M. L. (2015). J Am Acad Dermatol 35 (1996): 284, 40. The effect of glucomannan on pregnancy constipation. Constipation: Understanding mechanisms and management [Abstract]. Tell your doctor about all your current medicines and any medicine you start or stop using. Am J Med 96 (1994): 188-90, 23. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fluconazole in the elderly. J Am Acad Dermatol 32 (1995): 525-6, 38. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. People can increase their levels by eating probiotic foods. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, 2. Download Article Dehydration leads to stools that are more difficult to pass. For other infections that may occur in different parts of the body: AdultsDoses of up to 400 milligrams (mg) per day. Because of this, some healthcare experts recommend increasing exercise to get the stool moving (23). Please note the date of last review or update on all articles. Cerner Multum, Inc. "Australian Product Information." One reported patient with AIDS experienced acute hepatic necrosis and hepatic failure about 3 weeks after starting this drug. Copyright 1996-2023 Cerner Multum, Inc. The Best Diets for Cognitive Fitness, is yours absolutely FREE when you sign up to receive Health Alerts from Harvard Medical School. Read about what you should eat and drink to help relieve constipation. Influence of coffee (. Although not all of these side effects may occur, if they do occur they may need medical attention. You should drink adequate amounts of water. The doctor may recommend temporarily removing dairy from the diet, while increasing other calcium-rich foods, to see if it improves the symptoms. Am J Health Syst Pharm 65 (2008): 619-23, 36. Insomnia has also been reported during postmarketing experience. It is a type of osmotic laxative that people can buy over the counter or online. Arch Intern Med 151 (1991): 1020-1, 20. Bottom line: The herbal laxative Senna is a popular remedy for constipation. The liquid form of Diflucan contains sucrose. To prevent this, it is important to drink enough water. 125 ounces (3.7 liters) for men. People often tout prunes and prune juice as natures remedy for constipation and for good reason. Try to get at least 25 grams of fiber daily from your diet. This is because increasing fiber intake increases the bulk and consistency of bowel movements, making them easier to pass. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Gastroparesis: What to Eat and What to Avoid, Newly Diagnosed With Crohn's? Infection 17 (1989): 121-3, 13. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. (2019). Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Limit caffeinated beverages such as soda and coffee, which can actually leach more fluid from your body. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Last updated on Dec 14, 2022. Learn more: Vaccines, Boosters & Additional Doses | Testing | Patient Care | Visitor Guidelines | Coronavirus. Ask your healthcare professional how you should dispose of any medicine you do not use. Diflucan is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, bladder, genital area, and the blood. As many as one in five people experiences chronic constipation, a condition that's even more common in women as they get older. Call your doctor if your symptoms do not improve, or if they get worse. Bottom line: Glucomannan may help treat constipation in some people. The patient went into complete remission when the drug was stopped. Your infection may not clear up if you stop using the medicine too soon. Do not keep outdated medicine or medicine no longer needed. This includes in people with indigestion, or dyspepsia, and people with chronic idiopathic constipation (9, 11). Holechek MJ "Medication review: fluconazole." Check with your doctor right away if you or your child have stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, or yellow eyes or skin. Transaminase elevations greater than 2 to 3 x ULN have also been reported. Symptoms include having bowel movements too infrequently (typically fewer than three times a week); having hard or small, lumpy stools; having stools that are hard to pass; straining; having painful bowel movements; or having the sensation of incomplete emptying after a bowel movement. This article looks at the link between stress and constipation and discusses ways to. A single copy of these materials may be reprinted for noncommercial personal use only. This medicine works by killing the fungus or yeast, or preventing its growth. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Try taking probiotic supplements, which are available online, or eating more probiotic-rich foods to see if this helps with constipation. To help prevent and treat constipation while taking Farxiga: large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, blistering, peeling, or loosening of the skin, muscle spasm or jerking of the arms and legs, numbness or tingling in the hands, feet, or lips, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, Fearfulness, suspiciousness, or other mental changes, seeing, hearing, or feeling things that are not there, change in taste or bad, unusual, or unpleasant (after) taste. Dermatol Clin 21 (2003): 469-79, vi, 10. Additionally, these foods are usually packed with fiber, water, and antioxidant compounds. Craig TJ, Peralta F, Boggavarapu J "Desensitization for fluconazole hypersensitivity." Bottom line: Laxatives are effective for relieving constipation. When a person is constipated, they might find relief from drinking some carbonated (sparkling) water. Guillaume MP, Deprez C, Cogan E "Subacute mitochondrial liver disease in a patient with AIDS: possible relationship to prolonged fluconazole administration." The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If your dose is different, do not change it unless your doctor tells you to do so. Shutterstock. These things are filled with pus, hurt like hell, and turn everyday activities like . Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. McMahon JH, Grayson ML "Torsades de pointes in a patient receiving fluconazole for cerebral cryptococcosis." Follow your doctor's orders or the directions on the label. For other infections, your first dose may be a double dose. Probiotics are live, beneficial bacteria that naturally occur in the gut. Eur J Clin Pharmacol 46 (1994): 115-8, 9. Masks are required inside all of our care facilities. Do not double doses. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem including QT prolongation. Chronic constipation has many possible causes. So can using a fiber supplement with psyllium seed or methylcellulose. Before blaming your diet, consider whether medication side effects are causing your constipation. Most side effects were of mild to moderate severity. Also, get sufficient fiber by eating: Fruits. Spontaneous reports of anemia were more frequent in patients 65 years of age or older than in those between 12 and 65 years of age; however, there is a natural increase in the incidence of anemia in the elderly. At Another Johns Hopkins Member Hospital: Masks are required inside all of our care facilities, COVID-19 testing locations on Maryland.gov, Fewer than three bowel movements per week, Straining to start or complete a bowel movement, Stool consistency that looks like rocks and pebbles. Most people think constipation means not having frequent enough bowel movements. Anemia, eosinophilia, leukopenia, neutropenia, and thrombocytopenia have been reported, often in patients with severe deep fungal infections or underlying disease. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. An 11-year-old male with neurofibromatosis-1 presented to the hospital in septic shock secondary to a perforated gastric volvulus. The total recommended fiber intake per day is 25 grams (g) for females and 38 g for males (14). Constipation: Pathophysiology and current therapeutic approaches [Abstract]. You may be able to treat and prevent your . Current and emerging treatments for irritable bowel syndrome with constipation and chronic idiopathic constipation: Focus on prosecretory agents [Abstract]. Pediatr Cardiol 29 (2007): 210-3, 35. Munoz P, Moreno S, Berenguer J, et al. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Over-the-counter or prescription laxatives, 9. Fluconazole is also used to prevent candidiasis in patients having bone marrow transplants who receive cancer or radiation treatment. That said, many of the natural home remedies in this article can provide significant relief. 22. In these people, removing dairy from the diet can help relieve symptoms. QT prolongation and torsade de pointes have also been reported during postmarketing experience. Does fluconazole flush out yeast/discharge? Fluconazole oral tablet is used to prevent and treat candidiasis, a fungal infection. 57. For non-prescription products, read the label or package ingredients carefully. Medical News Today only shows you brands and products that we stand behind. We include products we think are useful for our readers. Children 6 months to 13 years of ageDose is based on body weight and must be determined by your doctor. Position of the Academy of Nutrition and Dietetics: Health implications of dietary fiber. Chronic constipation: A review of current literature [Abstract]. 2. Experts explain how to tell if you have inflammation. The patient presented with increasing generalized edema accompanied by nausea and indigestion for 3 weeks. 91 ounces (2.7 liters) for women. Franklin IM, Elias E, Hirsch C "Fluconazole-induced jaundice." Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Use Diflucan for the full prescribed length of time, even if your symptoms quickly improve. 7. If your or your child's symptoms do not improve, or if they become worse, check with your doctor. Not all possible interactions are listed here. Lancet 338 (1991): 120, 31. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. It does this by blocking the effects of an enzyme called lanosterol 14--demethylase which is responsible for the formation of ergosterol, an important component of the yeasts cell wall. Vincent-Ballereau FN, Patey ON, Lafaix C "Fluconazole: review and situation among antifungal drugs in the treatment of opportunistic mycoses of human immuno-deficiency virus infections." If you think you have become pregnant while using this medicine, tell your doctor right away. Children 6 months to 13 years of ageDose is based on body weight and must be determined by your doctor. Eat more fiber, especially soluble, non-fermentable fiber, 4. Important warnings. It also helps them pass through the digestive system more quickly (14). Before taking Diflucan, tell your doctor if you have liver disease, kidney disease, a heart rhythm disorder, or a history of Long QT syndrome. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Dried plums and their products: Composition and health effects--An updated review [Abstract]. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This includes prescription and over-the-counter medicines, vitamins, and herbal products. 2) Insufficient Fiber in Their Diet. Reasons include a blockage and a low fiber diet. This effect was 60% stronger than drinking water and 23% stronger than drinking decaffeinated coffee (31). Bozzette SA, Larsen RA, Chiu J, et al. 3. The effective dosage may be around 50 g, or seven medium prunes, twice per day (59). It's a necessary aspect to helping our body stay healthy and . To treat constipation, doctors often tell people to increase their dietary fiber intake. Liver diseaseUse with caution. Health Alerts from Harvard Medical School. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Last medically reviewed on January 23, 2023, This article looks at some possible natural alternatives to laxatives for people looking to have a bowel movement. Here are 13 natural home remedies to relieve constipation. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. This is known as chronic idiopathic constipation. May make these conditions worse. Rev Infect Dis 12 (1990): s349-63, 8. Goodman JL, Winston DJ, Greenfield RA, et al. fluconazole, nystatin, nystatin topical, clotrimazole, clotrimazole topical, ketoconazole, itraconazole, cisplatin, miconazole, miconazole topical. Copyright 2023 IBM Watson Health. Anemia, leukopenia, neutropenia, agranulocytosis, and thrombocytopenia have also been reported during postmarketing experience. Learn more about prune juice for constipation and other juices for constipation here. Fluconazole - can you drink alcohol while using one dose of 150mg one time? Evidence-based approach to fiber supplements and clinically meaningful health benefits, part 2: What to look for and how to recommend an effective fiber therapy. Different types have varying methods of action, but all are effective for constipation (40, 41). Thomas, R. H., & Luthin, D. R. (2015). These include treatments for urinary. [5] If you don't eat dairy, try vegan yogurt, which also contains helpful probiotics. Costilla, V. C., & Foxx-Orenstein, A. E. (2014). The average household teaspoon may not hold the right amount of liquid. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Rare cases of seizures have been reported, but a causal relationship was difficult to establish, since some of these patients had cryptococcal meningitis or severe underlying disease. Fluconazole inhibits the growth of the yeast Candida albicans, which is most commonly responsible for Vaginal yeast infections. Doctors consider Senna safe for adults for short periods of time, but people should consult a doctor if their symptoms do not go away after a few days. Your doctor may adjust your dose as needed. Speak to a doctor or pharmacist about the best ones to use. People may experience constipation due to the foods they eat or avoid, their lifestyle choices, the medications they take, or the medical conditions they have. Studies have linked sedentary lifestyles with an increased risk of constipation. Other things you can do to relieve constipation include: Exercise regularly. Shear NH "Alopecia associated with fluconazole therapy." The effects may be increased because of slower removal of the medicine from the body. Keep from freezing. Soluble fibers present in oat bran, barley, nuts, seeds, beans, lentils, and peas, as well as some fruits and vegetables absorb water and form a gel-like paste, which softens the stools and improves its consistency. Many drugs can interact with fluconazole, and some drugs should not be used at the same time. Serious skin reactions can occur in certain people during treatment with this medicine. Blockages in the colon or rectum. O 0, 5. To prevent constipation, people should aim to consume a mix of soluble and insoluble fibers. J Am Acad Dermatol 58 (2008): 521-522, 33. Try adding 1 tsp of magnesium sulfate or Epsom salt to 6 to 8 fl oz (180 to 240 ml) of water to help relieve constipation in as soon as 30 minutes. Prebiotics may help relieve constipation. Constipation is uncomfortable and has a number of potential underlying causes. You or your child should not use erythromycin (Ery-Tab), pimozide (Orap), or quinidine (Cardioquin) while using this medicine because of the risk of unwanted side effects. Ask a doctor if it is safe to breastfeed while using this medicine. It's also used to treat meningitis (infection of the brain or spinal cord, or both). Moving your body will keep your bowels moving, too. Certain other drugs can cause unwanted or dangerous effects when used with Diflucan,especially cisapride, erythromycin, pimozide, quinidine, astemizole, higher doses of terfenadine, and many other medications that are broken down by certain enzymes that are inhibited by fluconazole. Some people who have chronic constipation have an imbalance of bacteria in their gut. 38. Alteration of gut microbiota and efficacy of probiotics in functional constipation. Bottom line: Taking magnesium citrate, an over-the-counter supplement, can help relieve constipation. Continue to take this medicine as directed. For some people, consuming coffee can increase the urge to go to the bathroom. This medicine works by killing the fungus or yeast, or preventing its growth. These conditions may increase your risk of having heart rhythm problems and make the effects of this medicine worse. In turn, they improve bowel movements and prevent constipation. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Drink more water Being dehydrated regularly can make a person constipated. Thompson GR 3rd, Cadena J, Patterson TF "Overview of antifungal agents." Lancet 336 (1990): 565, 19. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. Glucomannan supplements are also available. AIDS 6 (1992): 191-4, 21. A causal relationship to drug exposure could not be determined. A clinical diagnosis of FDE due to drug therapy was made. Proton-pump inhibitors: Should I still be taking this medication? Ann Intern Med 113 (1990): 899, 37. A 58-year-old female with a history of hypertension and cervical cancer experienced membranous nephropathy coincident with this drug. Kombucha tea. Therapy discontinuation occurred in 1.5% and 1.3% of patients due to adverse clinical events and laboratory test abnormalities, respectively. Fiber is critical, because most of our stool is actually made up of bacteria, and fiber provides the bacteria a good place to grow. Anticholinergics, a large class of medications found in many over-the-counter and prescription medications. Bray, G. A. This drug was generally well tolerated. The FDE was confirmed when the patient was rechallenged with a 25 mg oral dose. Achieving this balance requires a 3-step process. Children 6 months to 13 years of ageDose is based on body weight and must be determined by your doctor. However, many home remedies and natural methods can help. Get emergency medical help if you have signs of an allergic reaction to Diflucan (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. These drugs relax the smooth muscles in blood vessels to lower blood pressure. 2023 by The President and Fellows of Harvard College, Do not sell my personal information | Privacy Policy. This causes toxic substances to build up inside the yeast, reducing its ability to build up and cause an infection. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. [Ref], Uncommon (0.1% to 1%): Thirst, fatigue, malaise, pain, rigors, asthenia, fever, flushing, hot flushes, Frequency not reported: Infection due to resistant microorganisms[Ref], Uncommon (0.1% to 1%): Back pain, myalgia, Frequency not reported: Joint pain, finger stiffness[Ref], Myalgia has also been reported during postmarketing experience.[Ref]. This is because coffee stimulates the muscles in the digestive system (29, 30). Fluconazole - How long does it take to work? However, safety and efficacy have not been established in children younger than 6 months of age. Continue reading. This medicine is available only with your doctor's prescription. The most common side effects reported in patients receiving a single 150 mg dose of this drug for vaginitis were headache, nausea, and abdominal pain. 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